Aspirin Induces Apoptosis through Release of Cytochrome c from Mitochondria
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منابع مشابه
Bax directly induces release of cytochrome c from isolated mitochondria.
Bax is a pro-apoptotic member of the Bcl-2 protein family that resides in the outer mitochondrial membrane. It is controversial whether Bax promotes cell death directly through its putative function as a channel protein versus indirectly by inhibiting cellular regulators of the cell death proteases (caspases). We show here that addition of submicromolar amounts of recombinant Bax protein to iso...
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This chapter addresses the role of mitochondria in apoptosis. Emphasis is put on the recently observed influence of ceramides on mitochondrial functions. We report here that N-acetylsphingosine (C2-ceramide), N-hexanoylsphingosine (C6-ceramide) and, to a much lesser extent, C2-dihydroceramide, induce cytochrome c (cyt c) release from isolated rat liver mitochondria. Ceramide-induced cyt c relea...
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ژورنال
عنوان ژورنال: Neoplasia
سال: 2000
ISSN: 1476-5586
DOI: 10.1038/sj.neo.7900120